Akt inhibitor

45-16 Ramsey Road, Shirley, NY 11967, USA, Long Island City, New York, 11967

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https://www.bocsci.com/tag/akt-51.html
Akt, or protein kinase B (PKB), is a Ser/Thr protein kinase that phosphorylates a variety of protein substrates to regulate numerous cellular functions. Such as protein synthesis, metabolism, transcription, cellular proliferation, cellular differentiation, migration, and apoptosis (programmed cell death) . GSK3, NF-κB, IκB , Rac, Rho, p70S6kinase, Caspase 9, mTOR, Chkl, TSC1/2 and ER are demonstrated targets of Akt, which when phosphorylated have altered enzyme activity, DNA binding ability, or subcellular localization.

Three human isoforms of Akt have been identified, Aktl, Akt2, and Akt3. The three Akt isoforms are ubiquitously expressed in mammals with varying levels of expression in different tissues. Aktl is the most predominant isoform in most tissues and Akt2 has its highest expression levels in the insulin-response tissues such as skeletal muscle, heart, liver, and kidney tissues. This expression pattern suggests that Akt2 is important in the insulin signaling pathway. Akt3 has a more restricted pattern of expression with the highest levels detected in the brain and testis tissues. The specific activities of the three isoforms have not been fully elucidated and their expression levels in various tissues and during differentiation may not reflect their activities.

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