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https://www.bocsci.com/tag/apc-67.html
Anaphase-Promoting Complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C's main function is to trigger the transition from metaphase to anaphase by tagging specific proteins for degradation. The three major targets for degradation by the APC/C are securin and S and M cyclins.

Composition of APC/C

APC/C is a multisubunit complex, and there are at least ten subunits in human cells and frog eggs, APC1 is the largest subunit of APC/C. The structural motifs of protein containing two large subunits Rpn1 and Rpn1 regulatory particle of non-AT-Pasein are identical to those of the 19s hat complex of proteasome, but the structural and functional significance of this similarity is not clear. APC2, a new member of the cullin protein family, is the only known APC/C subunit that can predict its function based on its protein sequence.