auristatins

Auristatins are a family of complex analogues to the native antineoplastic product dolastatin 10. They are 100 to 1000 times more toxic than Doxorubicin, a conventional cancer chemotherapy medication. The potent agent, dolastatin 10 is a five-subunit penta-peptide discroverde by Pettit et al. from the sea hare Dolabella auricularia in 1987 and chemical modification to dolastatin 10 were applied to generate auristatins. https://www.creative-biolabs.com/adc/auristatins.htm