c-Kit Inhibitor
(631) 619-7922
45-1 Ramsey Road, Shirley, NY 11967, USA, Long Island City, New York, 11967
About us
Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor protein-tyrosine kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. c-Kit consists of an extracellular domain, a transmembrane segment, a juxtamembrane segment, and a protein kinase domain that contains an insert of about 80 amino acid residues. Binding of stem cell factor to Kit results in receptor dimerization and activation of protein kinase activity.
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