Cryo-EM Services

Electron microscopy (EM) has become an extremely popular method for the ultrastructural study of macromolecules, cells and tissues. An aqueous biological sample is frozen rapidly and irradiated with a beam of electrons. A detector senses how the electrons are scattered and a computer reconstructs the 3Dshape of the molecule.
Why you need this service? • You have small amount of materials; • The material is hard to crystallize; • You are looking into the molecules in atomic details; • It is a large biomolecular complex (>150 kDa, up to 2000 Å); • You want to observe the real "native state" structure. See the comparison of Crystallography, NMR, and EM Service Processes: (Take protein as an example)

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