epitope

Creative Biolabs together with our sister company Creative Biostructure has been a leader in commercializing a comprehensive panel of methodologies in mapping both linear and conformational epitopes of monoclonal antibodies. Epitopes consist of groups of amino acids that lie close together on the protein (antigen) surface and interact with an antibody; they therefore determine antigenicity. Epitopes of proteins are usually classified as either linear (continuous) or conformational (discontinuous). Conformational epitopes are thought to form the majority of epitopes on most proteins. However, many conformational epitopes may also be recognizable as linear epitopes.