GALR1 Total GPCR Internalization Assay Kit
45-1 Ramsey Road Shirley, New York 11967, USA, Shirley, New York, 11967
About us
Total GPCR Internalization cells are engineered to co-the ProLink (PK) tagged GPCR, and an Enzyme Acceptor (EA) tag localized to the endosomes. Activation of the GPCR-PK induces internalization of the receptor in EA-tagged endosomes, forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. These cells have been modified to prevent long term propagation and expansion using a proprietary compound that has no apparent effect on assay performance.
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