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https://www.bocsci.com/gamma-secretase-signalling-pathway.html
γ-secretase, a four subunit protease complex, works as an integral membrane protein that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. γ-secretase cleaves over 100 type-1 membrane proteins. Among all substrates that γ-secretase cleaved, amyloid precursor protein (APP) and Notch receptor are mostly studied due to their essential role in Alzheimer's disease (AD) pathogenesis and cancer development, respectively. Though, γ-secretase is also very important in other signal transduction pathway, such as receptor tyrosine kinases (RTK) pathway. γ-secretase maturation and its’ hardcore function in amyloidogenic pathway and notch pathway will be discussed below. Also, some inhibitors of γ-secretase, which appeal to the scientists, are expected to be potential drugs of AD and cancers induced by γ-secretase mutations.