ICOS Inhibitor
About us
ICOS is a newly discovered costimulatory molecule. The costimulatory signal provided by ICOS on activated T cells can promote the proliferation of T cells, regulate the differentiation of T cells, and maintain the effect and function of activated T cells (including memory T cells). ICOS is a member of immunoglobulin superfamily, which is composed of 199 amino acids and is divided into three parts: extracellular Ig-V-like domain, transmembrane domain and cytoplasmic tail. ICOS, as a costimulatory molecule, is expressed only on activated T cells, promoting T cell differentiation and exerting effect. In addition, ICOS can protect memory T cells from apoptosis and promote T cell proliferation and cytokine secretion.
https://www.bocsci.com/tag/icos-16.html