immunogenicity prediction

"EpiMatrix method to illustrate the basic process of screening a protein therapeutic for immunogenicity is showing as follows.
Firstly, the protein sequence is parsed into overlapping 9-mer peptide frames;
Then each of which is measured for binding potential to each of eight general class II HLA alleles that ‘cover’ the genetic backgrounds of most humans worldwide;
Finally, normalization of allelespecific scores allows it available to compare scores of any 9-mer across multiple HLA alleles and enables immunogenicity prediction on a global scale." https://www.creative-biolabs.com/preciab/antibody-immunongenicity-prediction.htm