JAK-STAT Signaling Pathway
About us
The cytokine-activated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. Dysregulation of JAK-STAT signaling is associated with various immune disorders. The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, proliferation, differentiation, apoptosis and oncogenesis. This pathway plays a prominent role in mediating signal transduction for many cytokines. Mechanistically, JAK-STAT signaling is relatively simple, the signaling cascade consists of three main components: a JAK binding receptor, a Janus kinase (JAK) and signal transducer and activator of transcription (STAT) protein.