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Cholesterol is an essential cellular component and maintenance of cholesterol homeostasis is critical for normal physiological functions. Elevated levels of plasma cholesterol are associated with various pathological conditions, most notably coronary heart disease where high cholesterol levels lead to foam cell formation and plaque buildup in arteries, potentially resulting in a heart attack or stroke. Regulation of cellular cholesterol metabolism and plasma cholesterol levels depends on low-density lipoprotein (LDL) receptor-mediated LDL uptake into specific cells.LDL is the major carrier of cholesterol in the blood, accounting for more than 60% of total plasma cholesterol. LDL is taken up by hepatic and extrahepatic tissues through receptor-mediated endocytosis triggered by apoB-100-LDL receptor interaction. The internalized LDL particle is transported to lysosomes where it isdegraded to free cholesterol and amino acids. In humans, the liver is the most important organ for LDL catabolism and LDL receptor activity. In the liver, LDL can be regulated by pharmacologic intervention.
https://www.creativebiomart.net/ldl-uptake-cell-based-assay-kit-463220.htm