Macrophage Polarization Signaling Pathway
45-1 Ramsey Road, Shirley, NY 11967, USA, https://www.creative-diagnostics.com/macrophage-polarization-signaling-pathway.htm, Shirley, New York, 11967
About us
Macrophages are tissue-resident professional phagocytes, which play an important role in immune-regulation. Activated macrophages are routinely classified into two different types: M1macrophages (classic activation) and M2macrophages (alternative activation). M1 macrophages are pro-inflammatory and have a central role in host defense against infection, while M2 macrophages are associated with responses to anti-inflammatory reactions and tissue remodeling, and they represent two terminals of the full spectrum of macrophage activation. M1–M2 polarization of macrophage is a tightly controlled process entailing a set of signaling pathways, transcriptional and posttranscriptional regulatory networks.