PCSK9[Biotinylated]-LDLR Binding Assay Kit
45-1 Ramsey Road, Shirley, New York 11967, USA, United States, Shirley, New York, 11967
About us
PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.
https://www.creativebiomart.net/pcsk9biotinylated-ldlr-binding-assay-kit-465692.htm