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Peptide N-Terminal Modification
Online InquiryOr by Phone: 1-631-624-4882
N-Terminal-Modification.pngAlthough many of the most widely recognized post-translational modifications are characteristic of secretory or cell-surface proteins, most proteins, whatever their ultimate cellular desination, undergo some modification. For proteins synthesized completely within the cytoplasm, the earliest and most widespread are removal or modification of the N-terminal residue. In many proteins the N-terminal α-ammonium group (PK=8) undergoes secondary modification.

N-terminal modification reduces overall solubility of the peptide by reducing its overall charges. However, the stability of the peptide could also be increased because N terminal modification generates a closer mimic of the native protein. Therefore, these modifications might increase the biological activity of a peptide and prevent degradation by enzymes.

Below is a list of our available N-terminal modifications (include but not limited to the following):

> 5-FAM/5-FAM-Ahx > Abz > Acetylation
> Acryl > Alloc > Benzoyl (Bz)
> Biotin/Biotin-Ahx > BOC > Benzyloxycarbonylation (CBZ)
> Chenodeoxycholic acid > Dansyl/Dansyl-Ahx > Decanoic acid
> D (+) Glucose > DNP > FITC/FITC-Ahx
> Fmoc > Formylation > Hexanoic acid
> Lauric acid > Lipoic acid > Maleimide
> 3-Mercaptopropyl (Mpa) > Myristoyl > Octanoic acid
> Palmitoyl > Pentinoic Acid > PEN
> Propiolic Acid > Pyroglutamyl (pGlu) (Pyr) > Stearic acid
> Succinylation > Tertbutoxycarbonyl (Boc) > TMR
Creative Peptides is specialized in the custom synthesis of N-terminal modification peptides, providing a confidential and efficient service at competitive prices. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. Typical delivery specifications include:

HPLC chromatogram
Mass spec analysis
Synthesis report
Certificate of Analyses

https://www.creative-peptides.com/services/peptide-n-terminal-modification.html