polysaccharide vaccine mechanism

https://www.creative-biolabs.com/vaccine/carbohydrate-conjugate-vaccine.htm
Polysaccharides, on killed cells or purified, can produce protective immune responses. Vaccination with polysaccharides reduced the need to vaccinate with the organism itself. When the polysaccharides are coupled to a carrier protein, they produce a much higher titer. Creative Biolabs is a world leader in vaccine services. We provide personalized design and development strategies for carbohydrate conjugate vaccine.

Various pathogenic bacteria have polysaccharide coats, many with repeated epitopes. Although polysaccharide vaccines have been available for some time, they predominately produce IgM and are only moderately protective in adults, not in young children. Polysaccharide vaccines are less immunogenic in children under 2 years of age. Since the study found that the immunogenicity of polysaccharides can be enhanced by conjugating to proteins. At least four different bacterial-specific polysaccharide-protein conjugates have been used in production and clinical trials over the past two decades. These bacteria usually cause quite high mortality and morbidity, especially in young children.