Safety Pharmacology

http://www.creative-animodel.com/Toxicology/Infusion-models-and-studies.html
Email: info@Creative-Animodel.com
Website: www.creative-animodel.com

Safety pharmacology is the study of the potential undesirable pharmacodynamic effects of a substance in relation to dosage within the substance's therapeutic range and above. It provides valuable insight into a drug's adverse effects, preview what may be observed clinically and provide essential information about likely side effects on the major physiological systems of the body. Creative Animodel offers a complete range of GLP-compliant ICH S7A core battery tests to determine the potential undesirable pharmacodynamic effects of a compound.

Our core battery services incorporate tests to detect effects on:
• Central Nervous System
• Cardiovascular System
• Respiratory System
In contrast to the core battery, some organ systems can be transiently disrupted without irreversible harm and are of less concern:

•Gastrointestinal System
Gastrointestinal Transit Time
Gastric Damage
Gastric Secretion (Pyloric Ligation)
•Renal System
•Additional Supplementary Tests
Abuse Liability Testing
Analgesic Assessment
Bleeding Time
Body Temperature
Motor-In Coordination (Rotarod)
Proconvulsant Activity
Sleeping Time

Creative Animodel consults with you to design animal study protocols balancing timing, cost and risk factors, ensuring appropriate data to support pre-clinical studies as well as the first human administration of new candidate drugs. Our regulatory expertise can also help with preparation of your submission.