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https://www.creative-peptides.com/services/stapled-peptide-design.html
Advantages of stapled peptides in drug design

The introduction of a hydrocarbon staple confers high levels of α-helical content and results in:
• SBetter target affinity (5 to 5,000-fold increase)
• STargeting of either extracellular or intracellular proteins
• SViable pharmacokinetics and in vivo stability
• SDisruption of protein-protein interactions
• SCell penetration through endocytic vesicle trafficking
• SIncreased proteolytic resistance and serum half-life
• SNon-immunogenicity

Available Stapled Peptide Design Services

Creative Peptides provides multiple methods for synthesizing stapled peptides. below is a list of our available strategies (include but not limited to the following):
• Grubbs catalysts are routinely used in olefin metathesis to incorporate hydrocarbon staples into peptides.